I am frequently asked about the appropriateness of taking antidepressants. Typically, I refrain from giving direct advice on the use of prescription drugs. Instead, I believe it is crucial for individuals dealing with depression to engage in open discussions with their healthcare provider to determine the most suitable treatment strategy for their specific situation. However, I can certainly offer some research data as a reference, beginning with an exploration of the effectiveness of antidepressants.
Effectiveness of Antidepressants
In a 2012 study [1], it was found that 10%-30% of people who took different antidepressants did not experience any improvement, referred to as “non-responders.” However, in a 2017 study [2], which included a timeline and a placebo control group, it was discovered that 40%-60% of patients who took antidepressants (TCA, SSRI, SNRI) reported symptom improvement within 6 to 8 weeks. However, even among those who took placebos, 20%-40% experienced symptom improvement. So, the effect of antidepressants can be seen as providing additional benefits to 20 out of 100 individuals, while 40%-60% of those taking antidepressants still do not respond to the treatment.
Side Effects of Antidepressants.
What are the side effects of antidepressants? In a study that compiled the side effect data of antidepressants and other commonly used nutraceuticals, researchers found several common side effects associated with two major classes of antidepressants: SSRIs and TCAs. These side effects include sexual dysfunction, daytime sleepiness, nighttime insomnia, weight gain, constipation, diarrhea, and more [3]。
Summary:
It’s important to understand that while antidepressants have shown effectiveness in alleviating depressive symptoms for some individuals, they may not work for everyone dealing with depression. Therefore, it is crucial to collaborate with your healthcare provider to develop a personalized treatment strategy that suits your specific needs.
Regardless of whether you decide to use antidepressants or explore other options, adopting a nutrient-dense and energy-light diet, along with increasing physical activity, can be beneficial. Not only does this approach improve your physiological health, but it also holds the potential to positively impact your mood.
References:
[1] Al-Harbi K. S. (2012). Treatment-resistant depression: therapeutic trends, challenges, and future directions. Patient preference and adherence, 6, 369–388. https://doi.org/10.2147/PPA.S29716
[2] Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-. Depression: How effective are antidepressants? 2015 Jan 28 [Updated 2017 Jan 12]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK361016/
[3] Bet, P. M., Hugtenburg, J. G., Penninx, B. W., & Hoogendijk, W. J. (2013). Side effects of antidepressants during long-term use in a naturalistic setting. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 23(11), 1443–1451. https://doi.org/10.1016/j.euroneuro.2013.05.001
